Life science engineering deals with the technical use of natural and life science findings. In the field of medical engineering, Hochschule Offenburg conducts research on cardiology (especially electrical stimulation and ablation) as well as on neurorobotics, hearing prosthetics, biomedical imaging and surgical navigation systems. In the field of biotechnology and environmental process engineering, the HSO focuses on biogas technology, thermal conversion processes and biological methanization.

The Peter Osypka Institute for Medical Engineering (POIM) is one of the participating institutes.